South African cricketer Makhaya Ntini (c) celebrates with teammates the dismissal of Pakistani captain Shoaib Malik [AFP]

Ntini tore through the top order with the new ball, taking four for 69 as Pakistan were bowled out for 249 in 46.3 overs in reply to South Africa's 294 for five.
 
The paceman struck in his second, third, fourth and sixth overs as the home team crumbled to 55 for four.
 
Mohammad Yousuf led the resistance with 53 before Shahid Afridi belted 47 with five fours and two sixes to lead a fightback.

Afridi put on 43 for the eighth wicket in 25 balls with debutant Sohail Tanvir, who cracked two sixes in his 26.

"We know he (Afridi) is dangerous and it surprised us they left him so late," South Africa captain Graeme Smith said.

"The game was a long way out of reach when he came in.

"We were always in control because when a team is seven or eight down it is pretty difficult to get back."

After Charl Langeveldt removed Misbah-ul-Haq (20), Yousuf and Kamran Akmal (35) put on 60 for the sixth wicket.

But Jacques Kallis then struck twice to have Yousuf caught at short mid-wicket by Smith and clean bowling Akmal to end the surge.

Dual centurions

Earlier, Gibbs (102) and de Villiers (103 not out) added 137 for the third wicket after South Africa chose to bat first and piled on a big score.

The two batsmen reached three figures for the second successive one-dayer, after their centuries against Zimbabwe in Harare in August.

It was Gibbs's 18th hundred in his 214th match while Villiers brought up his third ODI century.

Gibbs was run out in the 43rd over, beaten by an accurate throw from square leg by Imran Nazir as he attempted a second run.

The second game in the five-match series is also in Lahore on Saturday.

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