The Taliban said three fighters attacked guards at he entrance and then stormed the building

"It was a suicide bomber and there are casualties. Our ambulances are busy but the number is unclear," Abdullah Fahim, a health ministry official, said.

Azizudin, a police official at the site, said Thursday's explosion caused massive damage to the building, which is located in the city centre, at a busy intersection.

The Taliban has claimed responsibility for the blast according to the AP news agency.

Zabiullah Mujahid, a Taliban spokesman, said three fighters stormed the building by throwing hand grenades at the guards at the main gate.

Abdul Jabar, a security guard near the building, said the bomber shot two policemen outside the ministry building before entering the large conference hall inside where he blew himself up.

One of the side walls of the building collapsed, while glass littered the roads nearby and office equipment was scattered over the area, a spokesman for the health ministry said.

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